The Cherokee Arts Center is located at 212 S. Water St. in Historic Downtown Tahlequah, Oklahoma. The Cherokee Arts Center is located directly behind the Cherokee Supreme Court Museum which is directly across the street from the Cherokee Courthouse Square. One block south from the Cherokee Arts Center is the Cherokee Prison Museum and a few blocks North is the Historic Female Seminary which is now known as Northeastern State University.
Located outside the Cherokee Arts Center is a mural depicting Southeastern Woodland art. There are prehistoric basket and pottery designs, some representing friendship and some water/wind movement in the mural. The figure itself is a stickball player based on prehistoric shell work surrounded by contemporary depictions of the Seven Clans.